The oxycodone in OXYCONTIN may possibly cause spasm on the sphincter of Oddi. Opioids may cause raises in the serum amylase. Consistently Consider patients with biliary tract illness, including acute pancreatitis, for worsening indicators.???? ????? ????? ????? ?? ???? ???????? ?? ????? ??? ?? ??????????? ???? ???? ????? ???? ????? ???? ?? ????? ??